Prostate Cancer Stem Cells

详细信息	查看全文 | 推荐本文 |

• 作者：Shi-Ming Tu¹ ; ^{stu@mdanderson.org} ; Sue-Hwa Lin²
• 关键词：Prostate cancer ; Castrate-resistant ; Cancer stem cells ; Stem cell niche ; Stem cell theory
• 刊名：Clinical Genitourinary Cancer
• 出版年：2012
• 期刊代码：pca93_15587673
• 类别：med
• 出版时间：June, 2012
• 卷：10
• 期：2
• 页码：69-76
• 文件大小：759 K

摘要

Stem cells have long been implicated in prostate gland formation. The prostate undergoes regression after androgen deprivation and regeneration after testosterone replacement. Regenerative studies suggest that these cells are found in the proximal ducts and basal layer of the prostate. Many characteristics of prostate cancer indicate that it originates from stem cells. For example, the putative androgen receptor-negative (AR^-) status of prostate stem cells renders them inherently insensitive to androgen blockade therapy. The androgen-regulated gene fusion TMPRSS2-ERG could be used to clarify both the cells of origin and the evolution of prostate cancer cells. In this review, we show that the hypothesis that distinct subtypes of cancer result from abnormalities within specific cell types鈥攖he stem cell theory of cancer鈥攎ay instigate a major paradigm shift in cancer research and therapy. Ultimately, the stem cell theory of cancers will affect how we practice clinical oncology: our diagnosis, monitoring, and therapy of prostate and other cancers.