Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y₁ receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of d

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• 作者：Patricia A. Jimé ; nez-Vasquez ; Zaida Diaz-Cabiale ; Laura Caberlotto ; Inmaculada Bellido ; David Overstreet ; Kjell Fuxe ; Aleks ; er A. Mathé
• 关键词：Neuropeptide Y mRNA ; NPY Y₁ receptor mRNA ; NPY Y₁ receptor binding ; Animal model of depression ; Electroconvulsive stimuli
• 刊名：European Neuropsychopharmacology
• 出版年：2007
• 期刊代码：95_0924977x
• 类别：med
• 出版时间：March 2007
• 卷：17
• 期：4
• 页码：298-308
• 文件大小：1811 K

摘要

Previously we reported that basal neuropeptide Y (NPY)-like immunoreactivity-(LI) in hippocampus of the “depressed” Flinders Sensitive Line (FSL) rats was lower compared to the control Flinders Resistant Line (FRL) and that electroconvulsive stimuli (ECS) raise NPY-LI in discrete brain regions. Here we studied NPY mRNA expression, NPY Y₁ receptor (Y₁) mRNA expression and binding sites, and behavior under basal conditions (Sham) and after repeated ECS. Baseline NPY and Y₁ mRNAs in the CA1–2 regions and dentate gyrus were lower while the Y₁ binding was higher in the FSL. ECS had larger effects on both NPY and behavior in the FSL rats. ECS increased NPY mRNA in the CA1–2, dentate gyrus and hypothalamus in FSL, but only in the dentate gyrus in FRL. ECS also increased Y₁ mRNA in the CA1–2, dentate gyrus and the parietal cortex in both strains, while in the hypothalamus the increase was observed only in the FSL rats. Consistently with Y₁ mRNA increase, Y₁ binding was downregulated in the corresponding regions. ECS decreased FSL immobility in the Porsolt swim test. These findings suggest that NPY is involved in depressive disorder and that antidepressant effects of ECS may in part be mediated through NPY.