Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat

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• 作者：Elizabeth Escudero^a ; ^b ; Fidel Toldrá ; ^a ; Miguel Angel Sentandreu^a ; Hitoshi Nishimura^b ; Keizo Arihara^b ; ^{arihara@vmas.kitasato-u.ac.jp}
• 关键词：Antihypertensive activity ; Peptide ; Pork meat ; Angiotensin I-converting enzyme ; Spontaneously hypertensive rat
• 刊名：Meat Science
• 出版年：2012
• 期刊代码：78_03091740
• 类别：abs
• 出版时间：July, 2012
• 卷：91
• 期：3
• 页码：382-384
• 文件大小：180 K

摘要

This study investigated the in vivo antihypertensive activity of three novel peptides identified in the in vitro digest of pork meat. These peptides were RPR, KAPVA and PTPVP and all of them showed significant antihypertensive activity after oral administration to spontaneously hypertensive rats, RPR being the peptide with the greatest in vivo activity. To our knowledge, this is the first report showing the in vivo antihypertensive action of the three peptides from nebulin (RPR) and titin (KAPVA and PTPVP), thus confirming their reported in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. These findings suggest that pork meat could constitute a source of bioactive constituents that could be utilized in functional foods or nutraceuticals.