Phylogenies without roots? A plea for the use of vouchers in molecular phylogenetic studies

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• 作者：F. Pleijel ; U. Jondelius ; E. Norlinder ; A. Nygren ; B. Oxelman ; C. Sch ; er ; P. Sundberg ; M. Thollesson
• 关键词：Cortical removal ; Glutamate excitotoxicity ; Basal ganglia ; Cell death ; Neuroprotection ; Parkinson disease
• 刊名：Molecular Phylogenetics and Evolution
• 出版年：2008
• 期刊代码：176_10557903
• 类别：bio
• 出版时间：July 2008
• 卷：48
• 期：1
• 页码：369-371
• 文件大小：142 K

摘要

We have explored the survival of dopaminergic cells of the substantia nigra pars compacta (SNc) in 6 hydroxydopamine (6OHDA)-lesioned rats with prior cortical removal. There were direct.com/scidirimg/entities/223c.gif" alt="not, vert, similar" title="not, vert, similar" border="0">35%more dopaminergic cells in the ventral sector of SNc (vSNc) of 6OHDA-lesioned rats that had prior cortical removal compared to those that did not. By contrast, there were no differences in dopaminergic cell number between these experimental groups in the ventral tegmental area (VTA) and the dorsal sector of SNc (dSNc). Hence, prior cortical removal in 6OHDA-lesioned rats neuroprotected vSNc—but not VTA or dSNc—dopaminergic cells from death.