The development of the circadian heart rate rhythm (CHR) in Asian infants

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• 作者：Toke Hoppenbrouwers ; ^{hoppenbrou@earthlink.net} ; Flavia Oliveira ; Stanislaus Sandarupa ; Michael Khoo ; Michael Neuman ; Rangasamy Ramanathan
• 关键词：CHIME ; Collaborative Home Infant Monitoring Evaluation ; CHR ; Circadian Heart Rate Rhythm ; HR ; Heart Rate ; IRB ; Institutional Review Board ; LIPI ; Limbaga Ilmu Penetahuan Indonesia ; PSG ; Polysomnogram ; QS ; Quiet sleep ; REM ; Rapid eye movement sleep ; SCN ; Su
• 刊名：Early Human Development
• 出版年：2012
• 期刊代码：82_03783782
• 类别：med
• 出版时间：July, 2012
• 卷：88
• 期：7
• 页码：555-561
• 文件大小：1753 K

摘要

Objective

To test the hypothesis that term-born Asian infants, at reduced risk to die of Sudden Infant Death Syndrome (SIDS) exhibit a circadian heart rate rhythm (CHR) at a later age than non-Asian term infants.

Method

Repeated overnight heart rate (HR) traces obtained with a battery-operated Polar S810i heart-rate monitor at home in 17 Asian Torajan infants in Indonesia, were compared with those of 52 non-Asian infants monitored as part of the Collaborative Home Infant Monitoring Evaluation (CHIME). HR was determined using a moving window averaging technique. A comparison of median HR during quiet sleep (QS) episodes (identified by minimum HR variability), established the presence of CHR.

Results

Seventy three percent of non-Asian CHIME infants 鈮?#xA0;7 weeks exhibited CHR compared to 45%of Asian Torajan infants. Between 8 and 12 weeks, 94%of non-Asian CHIME infants exhibited CHR, compared to 33%of Asian Torajan infants (p < 0.001). Forty seven and 56%of Asian Torajan infants exhibited the CHR at the age intervals of 16-20 weeks and 21-25 weeks respectively. Active wakefulness percentages as a function of the entire recording and median QS HR were not significantly different in the two groups.

Conclusion

Despite the fact that Asian Torajan infants were on average a week older than non-Asian CHIME babies, between two and three months of age only one in three exhibited the CHR, compared to virtually all non-Asian CHIME infants. We speculate that the cause of this difference rests in the infants' environment rather than their genetic origin.