PPAR纬 as a therapeutic target in cystic fibrosis

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• 作者：Johanna F. Dekkersp>1p>p> ; p>p>2p>p> ; p>p>3p> ; Cornelis K. van der Entp>1p> ; Eric Kalkhovenp>2p>p> ; p>p>4p>p> ; p>p>5p> ; Jeffrey M. Beekmanp>1p>p> ; p>p>2p>p> ; p>p>3p>p> ; p>p>jbeekman@umcutrecht.nlp>
• 关键词：PPAR纬 ; cystic fibrosis ; pulmonary inflammation ; PPAR纬 ligand ; resolution.
• 刊名：Trends in Molecular Medicine
• 出版年：2012
• 期刊代码：259_14714914
• 类别：med
• 出版时间：May, 2012
• 卷：18
• 期：5
• 页码：283-291
• 文件大小：3377 K

摘要

Cystic fibrosis (CF) is characterized by a proinflammatory pulmonary condition that may result from increased infections and altered intracellular metabolism in CFTR-deficient cells. The lipid-activated transcription factor peroxisome proliferator-activated receptor-纬 (PPAR纬) has well-established roles in immune cell function and inflammatory modulation and has been demonstrated to play an important role in the heightened inflammatory response in CF cells. Here, we summarize current literature describing PPAR纬-dependent alterations of CF cells and discuss the potential of PPAR纬 ligands for treating CF.