The effect of chlorotrimethylsilane on bonding of nano hydroxyapatite with a chitosan-polyacrylamide matrix

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• 作者：Aravind Bhat Kalambettu ; Padmavathi Rajangam ; Sangeetha Dharmalingam ; ^{sangeetha@annauniv.edu}
• 关键词：Chitosan ; Polyacrylamide ; Chlorotrimethylsilane ; Blend ; Nano hydroxyapatite ; Composite
• 刊名：Carbohydrate Research
• 出版年：2012
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：1 May, 2012
• 卷：352
• 期：Complete
• 页码：143-150
• 文件大小：821 K

摘要

Stimuli sensitive biodegradable polymers have important applications in the fields of drug delivery and tissue engineering. In this study, biodegradable composite films of chitosan-polyacrylamide-nano hydroxyapatite (Cs-PAAm-nHA) with different concentrations of Chlorotrimethylsilane (CTMS) were fabricated and characterized using Fourier transform infrared (FTIR) spectroscopy. FTIR and XRD results suggested that CTMS functioned to couple nHA with the Cs-PAAm polymer matrix. The swelling study indicated that the formation of numerous CTMS based inter-chain bridges and pores facilitated water absorption and swelling. Hence, incorporation of CTMS into Cs-PAAm-nHA composites not only improved their stability but also controlled the degradation of the composites, which are important for drug delivery applications.