Paget's disease of the bone after treatment with Denosumab: A case report

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• 作者：Peter Schwarz^a ; ^d ; ^{petsch02@glo.regionh.dk} ; Anne Qvist Rasmussen^a ; Torben M. Kvist^a ; Ulrik B. Andersen^b ; Niklas R. Jø ; rgensen^c
• 关键词：Pagets disease ; Bone ; Denosumab treatment
• 刊名：Bone
• 出版年：2012
• 期刊代码：39_87563282
• 类别：med
• 出版时间：May, 2012
• 卷：50
• 期：5
• 页码：1023-1025
• 文件大小：351 K

摘要

Bone affection in Paget's disease is characterized by increased bone turnover localised at one or more sites of the skeleton. Bisphosphonates are the drugs of choice when treating the increased bone turnover in Paget's disease. However, in cases of decreased kidney function only less effective treatments that are available as bisphosphonates are contraindicated in these patients. We present a case of a male patient aged 86 years with GFR of 11 mL/min and Paget's disease successfully treated by Denosumab. The bone turnover and pain decreased upon treatment.