Ochratoxin A levels in human serum and foods from nephropathy patients in Tunisia: Where are you now?

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• 作者：K. Hmaissia Khlifa^a ; ^{azziz_mk@yahoo.fr} ; R. Ghali^b ; C. Mazigh^a ; Z. Aouni^a ; S. Machgoul^a ; A. Hedhili^b
• 关键词：Ochratoxin A ; Human nephropathy ; HPLC ; Foods analyze ; Tunisia
• 刊名：Experimental and Toxicologic Pathology
• 出版年：2012
• 期刊代码：128_09402993
• 类别：med
• 出版时间：July, 2012
• 卷：64
• 期：5
• 页码：509-512
• 文件大小：200 K

摘要

Ochratoxin A is a natural mycotoxin with nephrotoxic properties that can contaminate food products. It has been detected in high amount in human serum collected from nephropathy patients, especially those categorized as having a chronic interstitial nephropathy of unknown etiology. In the present study, ochratoxin A levels were measured in commonly consumed food items and in serum samples from nephropathy and healthy subjects in Tunisia. To assess ochratoxin A, a high performance liquid chromatography method was optimized. The ochratoxin A assay showed very different scales of ochratoxin A serum and food contamination from 0.12 to 1.5 ng/mL and 0.11 to 6.1 ng/g respectively, and in healthy subjects and 0.11 to 33.8 ng/g for food and 0.12 to 3.8 ng/mL for serum in nephropathy patients suffering from chronic interstitial nephropathy of unknown etiology. The disease seems related to ochratoxin A serum levels and food contaminations, since the healthy group was significantly different from the nephropathy group (P < 0.001) for both food and serum ochratoxin A contamination. Those results combined with data published already, emphasize the likely endemic aspect of ochratoxin A-related nephropathy occurring in Tunisia.