CNS regulation of appetite

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• 作者：Joanne A. Harrold^a ; ^{harrold@liverpool.ac.uk} ; Terry M. Dovey^b ; John E. Blundell^c ; Jason C.G. Halford^a
• 关键词：Appetite ; Food intake ; Peripheral ; Central ; Hunger ; Satiety
• 刊名：Neuropharmacology
• 出版年：2012
• 期刊代码：33_00283908
• 类别：pha
• 出版时间：July, 2012
• 卷：63
• 期：1
• 页码：3-17
• 文件大小：650 K

摘要

This article reviews the regulation of appetite from a biopsychological perspective. It considers psychological experiences and peripheral nutritional systems (both episodic and tonic) and addresses their relationship with the CNS networks that process and integrate their input. Whilst such regulatory aspects of obesity focus on homeostatic control mechanisms, in the modern environment hedonic aspects of appetite are also critical. Enhanced knowledge of the complexity of appetite regulation and the mechanisms that sustain obesity indicate the challenge presented by management of the obesity epidemic. Nonetheless, effective control of appetite expression remains a critical therapeutic target for weight management. Currently, strategies which utilise a combination of agents to target both homeostatic and hedonic control mechanisms represent the most promising approaches.

This article is part of a Special Issue entitled 鈥楥entral Control of Food Intake鈥?