Increased levels of 8-hydroxy-2鈥?deoxyguanosine are attributable to organophosphate pesticide exposure among young children

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• 作者：Guodong Ding^a ; ^b ; Song Han^c ; Pei Wang^d ; Yu Gao^e ; Rong Shi^e ; Guoquan Wang^f ; Ying Tian^a ; ^e ; ^{tianmiejp@yahoo.com.cn}
• 关键词：Organophosphate pesticide ; Oxidative stress ; 8-Hydroxy-2&prime ; -deoxyguanosine ; Children ; China
• 刊名：Environmental Pollution
• 出版年：2012
• 期刊代码：28_02697491
• 类别：env
• 出版时间：August, 2012
• 卷：167
• 期：Complete
• 页码：110-114
• 文件大小：142 K

摘要

Oxidative damage has been proposed as an important mechanism linking pesticide exposure to health effects. A study of 268 young Shanghai children was conducted to examine the relationship between organophosphate pesticide (OP) exposure and a biomarker of oxidative DNA damage. Urine samples were analyzed for five nonspecific dialkyl phosphate (DAP) metabolites [dimethyl phosphates (DMs) and diethyl phosphates (DEs)] and 8-hydroxy-2鈥?deoxyguanosine (8-OHdG). The creatinine-adjusted median of 8-OHdG in urine samples was 3.99 ng/mg. Increased exposure to OPs was associated with greater levels of urinary 8-OHdG [total DAPs: 脽 (adjusted) = 0.46 per log₁₀ unit increase, 95%confidence interval (CI) = 0.40-0.53, p = 0.000; DMs: 脽 (adjusted) = 0.34, 95%CI = 0.28-0.41, p = 0.000; DEs: 脽 (adjusted) = 0.48, 95%CI = 0.42-0.54, p = 0.000]. Thus, the 8-OHdG biomarker is useful for increasing our understanding of the link between childhood exposure to OPs and health outcomes.