Organophosphate pesticide exposure and perinatal outcomes in Shanghai, China

详细信息	查看全文 | 推荐本文 |

• 作者：Pei Wang^a ; ^b ; ^{stefnia.elle@yahoo.com.cn} ; Ying Tian^a ; ^c ; ^{tianmiejp@yahoo.com.cn} ; Xiao-Jin Wang^d ; ^{wxj106@163.com} ; Yu Gao^a ; ^{gaoyu_ciel@yahoo.com.cn} ; Rong Shi^a ; ^{sr1234@yahoo.cn} ; Guo-Quan Wang^e ; Guo-Hua Hu^e ; Xiao-Ming Shen^c ; ^{xmshen@shsmu.edu.cn}
• 关键词：CDC ; Centers for Disease Control and Prevention ; CV ; coefficient of variation ; DAP ; dialkylphosphate ; DEDTP ; diethyldithiophosphate ; DEP ; diethylphosphate ; DETP ; diethyldithiophosphate ; DMP ; dimethylphosphate ; DMTP ; dimethylthiophosphate ; LOD ; Limit of De
• 刊名：Environment International
• 出版年：2012
• 期刊代码：25_01604120
• 类别：env
• 出版时间：July, 2012
• 卷：42
• 期：Complete
• 页码：100-104
• 文件大小：175 K

摘要

Although pesticide use is widespread in China, little is known about levels of exposure to organophosphate pesticides in the population and its potential adverse health effects. We investigated levels of organophosphate exposure in pregnant women and the association between organophosphate exposure and perinatal outcomes in Shanghai, China, by enrolling 187 healthy pregnant women between September 2006 and January 2007. Pesticide exposure was assessed by a questionnaire administered to the mothers in the hospital after delivery as well as by analyses of maternal urinary nonspecific metabolites of organophosphate pesticides (dimethyl and diethyl phosphates). Information on birth weight and length was collected from medical records. Geometric means of metabolites were 25.75 渭g/L for dimethylphosphate (DMP); 11.99 渭g/L for dimethylthiophosphate (DMTP); 9.03 渭g/L for diethylphosphate (DEP); and 9.45 渭g/L for diethyldithiophosphate (DETP). We found that a log unit increase in urinary DEP was associated with a decrease in gestational duration in girls by 1.79 weeks. [脽_adjusted = 鈭?#xA0;1.79 weeks per log₁₀ unit increase; 95%confidence interval (CI), 鈭?.82 to 鈭?#xA0;0.76; p = 0.001]. These data suggest that high pesticide level might adversely affect duration of gestation although this association was not present among boys. No associations for any of the organophosphate exposure measures were present for birth weight and length, suggesting that organophosphate pesticides may have no effects on fetal growth. Given that maternal urine pesticide levels in Shanghai were much higher than those reported in developed countries, more studies on the effects of in utero organophosphate exposure on fetal growth and child neurodevelopment are warranted.