Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang-Lian-Jie-Du-Tang

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• 作者：Huaxu Zhu^a ; ¹ ; ^{Huaxuzhu@gmail.com} ; Zhilei Qian^a ; ¹ ; Huan Li^a ; Liwei Guo^a ; Linmei Pan^a ; Qichun Zhang^a ; Yuping Tang^b ; ^{yupingtang@njutcm.edu.cn}
• 关键词：Huang-Lian-Jie-Du-Tang ; Integral pharmacokinetic ; Components classification ; AUC-weighting approach ; Correlation between pharmacokinetics and effect
• 刊名：Journal of Ethnopharmacology
• 出版年：2012
• 期刊代码：26_03788741
• 类别：pha
• 出版时间：7 May, 2012
• 卷：141
• 期：1
• 页码：158-169
• 文件大小：1528 K

摘要

Ethnopharmacological relevance

Huang-Lian-Jie-Du-Tang (HLJDT, or Oren-gedoku-to in Japanese), an important multi-herb remedy in China and other Asia countries, has been used clinically to treat cerebral ischemia for decades.

Materials and methods

According to the previous studies we have reported, an HPLC method was developed and validated for determination of berberine, palmatine, baicalin, baicalein and geniposide simultaneously in MCAO rat plasma after administration of HLJDT aqueous extract. A classified integral pharmacokinetic method was put forward after having compared the integrated concentration-time profile with that of single component. An AUC based weighting approach was used for integrated principle.

Results

The results indicated the classified integral pharmacokinetic profile of index components from HLJDT could reveal the pharmacokinetic behavior of original components, and was corresponding to the holistic pharmacological effects of anti-ischemia with HLJDT.

Conclusions

This study was aimed to explore an approach that could be applied to integrate the pharmacokinetic behavior of different components derived from HLJDT. The integrated pharmacokinetic results also provided more information for further understanding of the clinical cerebrovascular disease in use of HLJDT.