Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents

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• 作者：Kazuo Matsubara^a ; Masaru Asari^b ; Manabu Suno^c ; Toshio Awaya^a ; Mitsuru Sugawara^d ; Tomohiro Omura^a ; ^b ; Joe Yamamoto^a ; Chikatoshi Maseda^b ; Yoshikazu Tasaki^a ; Hiroshi Shiono^b ; Keiko Shimizu^b ; ^{okeichan@asahikawa-med.ac.jp}
• 关键词：Methamphetamine ; Pharmacokinetic model ; Traffic accident ; Vehicular homicide
• 刊名：Legal Medicine
• 出版年：2012
• 期刊代码：185_13446223
• 类别：med
• 出版时间：July, 2012
• 卷：14
• 期：4
• 页码：191-196
• 文件大小：578 K

摘要

When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.