Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks
- 作者：Elizabeth A. Bobeck ; Kimberly S. Burgess ; Taylor R. Jarmes ; Michelle L. Piccione ; Mark E. Cook ; mcook@wisc.edu
- 关键词：FGF-23 ; Anti-FGF-23 antibody ; Phosphate requirement ; Chicken ; Dietary phosphate ; Plasma phosphate
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2012
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：13 April, 2012
- 卷：420
- 期：3
- 页码：666-670
- 文件大小：418 K
摘要
Phosphate in manure of monogastric animals pollutes the environment if improperly applied to soil. Strategies that reduce phosphate inputs into animal production systems reduce environmental pollution. Using a novel vaccine to fibroblast growth factor-23 (FGF-23), we induced neutralizing antibodies that reduced the phosphate requirement of growing chickens. Breeding hens were injected with a FGF-23 peptide (AFLPGMNP) conjugate. Antibody was passively transferred from hen to chick and chick response to deficient dietary phosphate intake was determined. Chicks without passive anti-FGF-23 antibody had a 43%and 21%reduction in blood phosphate and bone ash, respectively, when fed a phosphate deficient diet and compared to chicks fed a phosphate replete diet (P < 0.05). Chicks with circulating anti-FGF-23 antibodies fed the phosphate deficient diet had plasma phosphate and bone ash that did not differ from chicks fed the phosphate replete diet (P > 0.05). Neutralization of FGF-23 offers a new approach to reduce phosphate requirements of farmed animals and may provide a new means to reduce phosphate pollution related to animal farming.