Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages

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• 作者：Soumyaditya Mula ; Debashish Banerjee ; Birija S. Patro ; Sayanti Bhattacharya ; Atanu Barik ; S ; ip K. B ; yopadhyay ; Subrata Chattopadhyay
• 关键词：Cells ; Lipids ; Photosensitization ; Protection
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2008
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：15 March 2008
• 卷：16
• 期：6
• 页码：2932-2938
• 文件大小：198 K

摘要

The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher reactivity with ¹O₂, as revealed from the rate constant values of ¹O₂ quenching by the respective phenolics. APC also prevented the detrimental effects of the Type II photosensitization-induced toxicity to mouse fibroblast L929 cells. The results suggest that APC may play an important role in protecting biological systems against damage, by eliminating ¹O₂ generated from certain endogenous photosensitizers.