Novel adhesive glove device (AGD) for active compression-decompression (ACD) CPR results in improved carotid blood flow and coronary perfusion pressure in piglet model of cardiac arrest

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• 作者：Jai P. Udassi^a ; ^d ; ^{judassi@ufl.edu} ; Sharda Udassi^e ; Andre Shih^f ; Melissa A. Lamb^a ; Stacy L. Porvasnik^d ; Arno L. Zaritsky^b ; Ikram U. Haque^c
• 关键词：Cardiopulmonary resuscitation ; Active compression&ndash ; decompression ; Pediatric resuscitation ; External chest compression ; Piglet cardiac arrest
• 刊名：Resuscitation
• 出版年：2012
• 期刊代码：236_03009572
• 类别：med
• 出版时间：June, 2012
• 卷：83
• 期：6
• 页码：750-754
• 文件大小：407 K

摘要

Objective

ACD-CPR improves coronary and cerebral perfusion. We developed an adhesive glove device (AGD) and hypothesized that ACD-CPR using an AGD provides better chest decompression resulting in improved carotid blood flow as compared to standard (S)-CPR.

Design

Prospective, randomized and controlled animal study.

Methods

Sixteen anesthetized and ventilated piglets were randomized after 3 min of untreated VF to receive either S-CPR or AGD-ACD-CPR by a PALS certified single rescuer with compressions of 100 min^鈭? and C:V ratio of 30:2. AGD consisted of a modified leather glove exposing the fingers and thumb. A wide Velcro patch was sewn to the palmer aspect of the glove and the counter Velcro patch was adhered to the pig's chest wall. Carotid blood flow was measured using ultrasound. Data (mean 卤 SD) was analyzed using one way ANOVA and unpaired t-test; p-value 鈮?#xA0;0.05 was considered statistically significant.

Results

Right atrial pressure (mm Hg) during the decompression phase was lower during AGD-ACD-CPR (鈭?.32 卤 2.0) when compared to S-CPR (0.86 卤 1.8, p = 0.0007). Mean carotid blood flow was 53.2 卤 27.1 (%of baseline blood flow in ml/min) in AGD vs. 19.1 卤 12.5%in S-CPR, p = 0.006. Coronary perfusion pressure (CPP, mm Hg) was 29.9 卤 5.8 in AGD vs. 22.7 卤 6.9 in S-CPR, p = 0.04. There was no significant difference in time to ROSC and number of epinephrine doses.

Conclusion

Active chest decompression during CPR using this simple and inexpensive adhesive glove device resulted in significantly better carotid blood flow during the first 2 min of CPR.