Effects of tau phosphorylation on proteasome activity

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• 作者：Qing-Guo Ren ; Xiao-Mei Liao ; Xiao-Qian Chen ; Gong-Ping Liu ; Jian-Zhi Wang
• 关键词：Alzheimer disease ; Tau ; Phosphorylation ; Proteasome
• 刊名：FEBS Letters
• 出版年：2007
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：3 April 2007
• 卷：581
• 期：7
• 页码：1521-1528
• 文件大小：293 K

摘要

Dysfunction of proteasome contributes to the accumulation of the abnormally hyperphosphorylated tau in Alzheimer’s disease. However, whether tau hyperphosphorylation and accumulation affect the activity of proteasome is elusive. Here we found that a moderate tau phosphorylation activated the trypsin-like activity of proteasome, whereas further phosphorylation of tau inhibited the activity of the protease in HEK293 cells stably expressing tau441. Furthermore, tau hyperphosphorylation could partially reverse lactacystin-induced inhibition of proteasome. These results suggest that phosphorylation of tau plays a dual role in modulating the activity of proteasome.