Clinical value of whole-blood interferon-gamma assay in patients with suspected pulmonary tuberculosis and AFB smear- and polymerase chain reaction-negative bronchial aspirates

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• 作者：Jaehee Lee^a ; Shin Yup Lee^a ; Seung Soo Yoo^a ; Seung Ick Cha^a ; Dong Il Won^b ; Jae Yong Park^a ; Won-Kil Lee^b ; Chang Ho Kim^a ; ^{kimch@knu.ac.kr}
• 关键词：Bronchoscopy ; QuantiFERON-TB Gold In-Tube ; Polymerase chain reaction ; Tuberculosis
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2012
• 期刊代码：79_07328893
• 类别：med
• 出版时间：July, 2012
• 卷：73
• 期：3
• 页码：252-256
• 文件大小：184 K

摘要

Combining a polymerase chain reaction (PCR) test with bronchoscopy is frequently performed to allow a rapid diagnosis of smear-negative pulmonary tuberculosis (PTB). However, limited data are available concerning clinical judgment in patients with suspected PTB and AFB smear- and PCR-negative bronchial aspirates (BA). The present study evaluated the usefulness of whole-blood QuantiFERON-TB Gold In-Tube (QFT) testing in these patients. Of 166 patients with suspected PTB who had undergone bronchoscopy because of smear-negative sputum or inadequate sputum production, 93 (56%) were diagnosed with culture-positive PTB. Seventy-four patients were either AFB smear- or PCR-positive. In the 75 patients whose BA AFB smear and PCR results were both negative, 19 were finally diagnosed with PTB by culture. The QFT test had a negative predictive value of 91%for PTB. The QFT test may be useful for excluding PTB in patients with suspected PTB whose BA AFB smear and PCR results are both negative.