The frequency distributions of 3 SNPs in P-selectin gene promoter (鈭?#xA0;2123C/G, 鈭?#xA0;1969A/G, 鈭?#xA0;1817T/C) and 3 SNPs in exon region (Ser290Asn, Val599Leu, Thr715Pro) were investigated by real-time PCR and high-resolution melting method among 314 Chinese Tibetans and 328 age- and sex-matched Han people.
The frequencies of the 鈭?#xA0;2123G and 鈭?#xA0;1817T alleles among the Tibetan population had no significant differences from those of the Han population. Among the Tibetan population, the G allele frequency of 鈭?#xA0;1969A/G and Ser290Asn were both higher than those of the Han population. Val599Leu and Thr715Pro did not show any polymorphism in the two populations. In the Tibetan population, 鈭?#xA0;2123C/G, 鈭?#xA0;1969A/G, 鈭?#xA0;1817T/C and Ser290Asn were in tight linkage disequilibrium with each other.
The frequency distributions of 鈭?#xA0;1969A/G and Ser290Asn polymorphisms in the Tibetan population were different from those in the Han population.