Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury
- 作者：Angela Douglass ; Karen Wallace ; Rebecca Parr ; Jennifer Park ; Elaine Durward ; Ian Broadbent ; Caroline Barelle ; Andrew J. Porter ; Matthew C. Wright
- 关键词：C1-3 ; Drug targeting ; Gliotoxin ; Stellate ; scAb ; MMP-13 ; Liver ; Fibrosis ; Myofibroblast
- 刊名：Journal of Hepatology
- 出版年：2008
- 期刊代码：162_01688278
- 类别：med
- 出版时间：July 2008
- 卷：49
- 期：1
- 页码：88-98
- 文件大小：2507 K
摘要
A three-dimensional, time-dependent, baroclinic, hydrodynamic and salinity model, UnTRIM, was performed and applied to the Danshuei River estuarine system and adjacent coastal sea in northern Taiwan. The model forcing functions consist of tidal elevations along the open boundaries and freshwater inflows from the main stream and major tributaries in the Danshuei River estuarine system. The bottom friction coefficient was adjusted to achieve model calibration and verification in model simulations of barotropic and baroclinic flows. The turbulent diffusivities were ascertained through comparison of simulated salinity time series with observations. The model simulation results are in qualitative agreement with the available field data.