Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition

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• 作者：Janice A. Husted^a ; ^{jhusted@uwaterloo.ca} ; Rashid Ahmed^b ; Eva W.C. Chow^c ; ^d ; Linda M. Brzustowicz^e ; Anne S. Bassett^c ; ^d
• 关键词：Familial schizophrenia ; Childhood adversity ; Early trauma ; Risk factor ; Genetic predisposition
• 刊名：Schizophrenia Research
• 出版年：2012
• 期刊代码：240_09209964
• 类别：med
• 出版时间：May, 2012
• 卷：137
• 期：1-3
• 页码：166-168
• 文件大小：139 K

摘要

There are few studies of environmental factors in familial forms of schizophrenia. We investigated whether childhood adversity or environmental factors were associated with schizophrenia in a familial sample where schizophrenia is associated with the NOSA1P gene. We found that a cumulative adversity index including childhood illness, family instability and cannabis use was significantly associated with narrow schizophrenia, independent of NOSA1P risk genotype, previously measured childhood trauma, covariates and familial clustering (adjusted odds ratio (95%confidence interval) = 1.55 (1.01, 2.38)). The results provide further support that early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.