Magnetic source imaging in non-lesional neocortical epilepsy: Additional value and comparison with ICEEG

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• 作者：Felix Schneider^a ; ^b ; ^{felix.schneider@uni-greifswald.de} ; Andreas V. Alexopoulos^a ; Zhong Wang^a ; Salah Almubarak^a ; Yosuke Kakisaka^a ; Kazutaka Jin^a ; Dileep Nair^a ; John C. Mosher^a ; Imad M. Najm^a ; Richard C. Burgess^a
• 关键词：Non-lesional neocortical epilepsy ; Magnetic source imaging ; Intracranial electroencephalography ; Epilepsy surgery outcome
• 刊名：Epilepsy & Behavior
• 出版年：2012
• 期刊代码：76_15255050
• 类别：neu
• 出版时间：June, 2012
• 卷：24
• 期：2
• 页码：234-240
• 文件大小：480 K

摘要

Objective

To investigate the utility of magnetic source imaging (MSI) for localizing the epileptogenic zone (EZ) and predicting epilepsy surgery outcome in non-lesional neocortical focal epilepsy (NLNE) patients.

Methods

Data from 18 consecutive patients with NLNE who underwent presurgical evaluation including intracranial electroencephalography (ICEEG) and MSI were studied. Follow-up after epilepsy surgery was 鈮?#xA0;24 months. Intracranial electroencephalography and MSI results were classified using a sublobar classification.

Results

Sublobar ICEEG focus was completely resected in 15 patients; seizure-free rate was 60%. Eight patients showed sublobar-concordant ICEEG/MSI results and complete resection of both regions; seizure-free rate was 87.5%. Seizure-free rate in cases not matching these criteria was only 30%(p = 0.013).

Conclusions

Magnetoencephalography is a useful tool to localize the EZ and determine the site of surgical resection in NLNE patients. When sublobar concordance with ICEEG is observed, MSI increases the predictive value for a seizure-free epilepsy surgery outcome in these patients.