Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger

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• 作者：Sun Hong Park^a ; Min Sik Kyeong^a ; Yuri Hwang^a ; Shi Yong Ryu^b ; Sang-Bae Han^a ; Youngsoo Kim^a ; ^{youngsoo@chungbuk.ac.kr}
• 关键词：1D10G ; 1-dehydro-10-gingerdione ; AP1 ; activating protein 1 ; Bis-ANS ; 1 ; 1&prime ; -bis(anilino)-4 ; 4&prime ; -bis(naphthalene)-8 ; 8&prime ; -disulfonate ; COX-2 ; cyclooxygenase 2 ; IFN ; interferon ; I魏B ; inhibitory 魏B ; IL ; interleukin ; iNOS ; inducible nitric oxide
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：23 March, 2012
• 卷：419
• 期：4
• 页码：735-740
• 文件大小：351 K

摘要

Myeloid differentiation protein 2 (MD-2) is a co-receptor of toll-like receptor 4 (TLR4) for innate immunity. Here, we delineated a new mechanism of 1-dehydro-10-gingerdione (1D10G), one of pungent isolates from ginger (Zingiber officinale), in the suppression of lipopolysaccharide (LPS)-induced gene expression of inflammatory cytokines. 1D10G inhibited LPS binding to MD-2 with higher affinity than gingerol and shogaol from dietary ginger. Moreover, 1D10G down-regulated TLR4-mediated expression of nuclear factor-魏B (NF-魏B) or activating protein 1 (AP1)-target genes such as tumor necrosis factor 伪 (TNF-伪) and interleukin-1尾, as well as those of interferon (IFN) regulatory factor 3 (IRF3)-target IFN-尾 gene and IFN-纬 inducible protein 10 (IP-10) in LPS-activated macrophages. Taken together, MD-2 is a molecular target in the anti-inflammatory action of 1D10G.