Generation of polymer nanocapsules via a membrane-extrusion emulsification approach

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• 作者：Wenjing Xu¹ ; Xi Yu¹ ; Ruijing Liang¹ ; Shanqin Liu ; Qianwei Tian ; Renhua Deng ; Jintao Zhu ; ^{jtzhu@mail.hust.edu.cn}
• 关键词：Emulsions ; Membrane-extrusion ; Nanoparticles ; Polymers ; Self-emulsification
• 刊名：Materials Letters
• 出版年：2012
• 期刊代码：59_0167577x
• 类别：ms
• 出版时间：15 June, 2012
• 卷：77
• 期：Complete
• 页码：96-99
• 文件大小：738 K

摘要

We describe a simple, effective concept for the fabrication of nanocapsules by combining membrane extrusion and self-emulsification approach. Uniform emulsion droplets containing polymers were firstly prepared through the extrusion strategy, and relatively uniform nanocapsules can thus be generated after complete removal of the organic solvent. Size and size distribution of the capsules can be easily tuned through varying initial polymer concentration and extrusion pass times. This facile approach can be extended to generate different biodegradable polymer nanocapsules which will find applications in the fields of drug delivery, bioimaging, and diagnostics.