Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy

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• 作者：X. Huang ; J. McMahon ; Y. Huang ; ^{huangy@mail.amc.edu}
• 关键词：AEDs ; anti-epileptic drugs ; mTOR ; mammalian target of rapamycin pathway ; SE ; status epilepticus ; TLE ; temporal lobe epilepsy ; TSC ; tuberous sclerosis complex
• 刊名：Neuroscience
• 出版年：2012
• 期刊代码：50_03064522
• 类别：neu
• 出版时间：26 July, 2012
• 卷：215
• 期：Complete
• 页码：90-97
• 文件大小：543 K

摘要

Psychiatric disorders are fairly common comorbidities of epilepsy in humans. Following pilocarpine-induced status epilepticus (SE), experimental animals not only developed spontaneous recurrent seizures, but also exhibited significantly elevated levels of aggressive behavior. The cellular and molecular mechanism triggering these behavioral alterations remains unclear. In the present study, we found that aggression is positively correlated with development of spontaneous seizures. Treatment with rapamycin, a potent mTOR (mammalian target of rapamycin pathway)-pathway inhibitor, markedly diminished aggressive behavior. Therefore, the mTOR pathway may have significance in the underlying molecular mechanism leading to aggression associated with epilepsy.