Association between the Pro12Ala polymorphism of PPAR-纬 gene and the polycystic ovary syndrome: A meta-analysis of case-control studies

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• 作者：Hong Zhang^a ; ^b ; ¹ ; Yan Bi^a ; ^c ; ¹ ; Changjun Hu^b ; Weiping Lu^b ; Dalong Zhu^a ; ^c ; ^{zhudalong@nju.edu.cn}
• 关键词：PPAR-纬 ; Peroxisome proliferator&ndash ; activated receptor 纬 ; PCOS ; Polycystic ovary syndrome ; ORs ; Odds ratios ; CIs ; Confidence intervals ; HOMA ; Homeostasis model assessment ; IR ; Insulin resistance ; OR ; Odds ratio ; TZDs ; Thiazolidinediones ; SNPs ; Single-
• 刊名：Gene
• 出版年：2012
• 期刊代码：73_03781119
• 类别：bio
• 出版时间：15 July, 2012
• 卷：503
• 期：1
• 页码：12-17
• 文件大小：689 K

摘要

Several studies have been conducted to examine the association between PPAR-纬2 Pro12Ala polymorphism and polycystic ovary syndrome (PCOS), but the results remain inconsistent. To make a more precise estimation of the relationship, a meta-analysis was performed. In the current meta-analysis, a total of 17 case-control studies, including 2176 cases and 2373 controls, were selected. Odds ratios (ORs) and 95%confidence intervals (CIs) for Pro/Ala + Ala/Ala versus Pro/Pro genotype in all population and different nationality groups, and homeostasis model assessment-insulin resistance (HOMA-IR) of different genotype were evaluated. In the overall analysis, significant association between PPAR-纬2 Pro12Ala polymorphism and reduced risk of PCOS was observed (OR = 0.75; 95%CI, 0.62-0.91; p = 0.003). Stratified analysis showed that significantly strong association was presented only in Europeans (OR = 0.74; 95%CI, 0.60-0.90; p = 0.003), but not in Asians (OR = 0.86; 95%CI, 0.51-1.43; p = 0.56). Additionally, carrying the Ala12 allele was not associated with HOMA-IR in PCOS patients (OR = 鈭?#xA0;0.29; 95%CI, 鈭?#xA0;0.82-0.24; p = 0.29). This meta-analysis supported that PPAR-纬2 Pro12Ala polymorphism was capable of reducing polycystic ovary syndrome risk in Europeans, but not in Asians.