The effect of bone marrow-derived cells on diastolic function and exercise capacity in patients after acute myocardial infarction

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• 作者：Meng Jiang ; Jialiang Mao ; Ben He ; ^{heben1025@126.com}
• 关键词：RCT ; Randomized controlled trial ; E/A ratio ; transmitral early peak (E)/late peak (A) velocities ; mitral E/Ea ; inflow E velocity to tissue Doppler Ea ratio ; IVRT ; isovolumic relaxation time ; DT ; E-wave deceleration time ; PVR ; pulmonary vascular resistance
• 刊名：Stem Cell Research
• 出版年：2012
• 期刊代码：P20_18735061
• 类别：bio
• 出版时间：July, 2012
• 卷：9
• 期：1
• 页码：49-57
• 文件大小：938 K

摘要

Background

The early- to mid-term impact of bone-marrow-derived stem cells (BMC) on diastolic function and exercise capacity after acute myocardial infarction (AMI) remains controversial. We performed a systematic analysis to assess whether BMC transfer is related to an early improvement in diastolic function and exercise capacity after AMI.

Methods

Randomized controlled trials (RCTs) of BMC therapy after AMI were extracted from MEDLINE, EMBASE and CENTRAL and analyzed for a change in tissue Doppler annular early (Ea) and late diastolic (Aa) velocities, mitral inflow E velocity to tissue Doppler Ea (E/Ea) ratio, exercise time and exercise capacity.

Results

A total of 365 patients were included from 6 trials. A greater improvement was observed in the E/Ea ratio after 1 year in the BMC group compared to the control group. Additionally, the BMC-treated patients had a larger improvement in exercise time, ventilation/CO₂ production (VE/VCO₂ slope) and respiratory exchange ratio (RER) after 1 year.

Conclusion

The results indicate that intracoronary BMC treatment in AMI patients leads to a mid-term improvement in diastolic function and exercise capacity.