Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine

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• 作者：Mariana Bendlin Calzavara ; Monica Levy Andersen ; Daniela Fukue Fukushiro ; Giorgia Batlle Lopez ; Vanessa Costhek Abí ; lio ; Sergio Tufik ; Roberto Frussa-Filho
• 关键词：Amphetamine ; Context-dependent behavioural sensitization ; Conditioning ; Mice ; Paradoxical sleep deprivation ; Sleep rebound
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2008
• 期刊代码：222_02785846
• 类别：med
• 出版时间：1 July 2008
• 卷：32
• 期：5
• 页码：1277-1282
• 文件大小：256 K

摘要

We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. In the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied on AMPH-induced behavioural sensitization. Sleep rebound attenuated the acute locomotor-stimulating effect of AMPH. AMPH-induced behavioural sensitization was context-specific and was also attenuated by sleep rebound. These results strengthen the notion that sleep conditions can influence AMPH-induced behavioural sensitization.