Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression

详细信息	查看全文 | 推荐本文 |

• 作者：Minna-Liisa Ä ; nkö ; Maria &#xd6 ; stergå ; rd ; Minnamaija Lintunen ; Pertti Panula
• 关键词：Neuropeptide FF2 receptor ; Alternative splicing ; Neuropeptide
• 刊名：FEBS Letters
• 出版年：2006
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：22 December 2006
• 卷：580
• 期：30
• 页码：6955-6960
• 文件大小：1298 K

摘要

Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5′ untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.