Perioperative retinoic acid syndrome in a patient with acute promyelocytic leukemia
- 作者：Nikolay A. Usoltsev ; MD ; usnickolay@gmail.com (Resident) ; M. Saeed Dhamee ; MD (Professor of Anesthesiology)
- 关键词：Acute promyelocytic leukemia ; All-trans retinoic acid (ATRA) ; Dexamethasone ; Pulmonary edema ; Retinoic acid syndrome
- 刊名：Journal of Clinical Anesthesia
- 出版年：2012
- 期刊代码：147_09528180
- 类别：med
- 出版时间：June, 2012
- 卷：24
- 期：4
- 页码：315-317
- 文件大小：98 K
摘要
All-trans retinoic acid (ATRA), a vitamin A derivative, is prescribed for induction of chemotherapy in patients with acute promyelocytic leukemia. Like other chemotherapy agents, ATRA has an adverse effect known as retinoic acid syndrome. The case of a 22 year old woman with acute promyelocytic leukemia, who received ATRA and subsequently developed retinoic acid syndrome, is presented. The patient's symptoms resolved after administration of dexamethasone, allowing the completion of chemotherapy without further complications.