T cells and cytokines in Crohn's disease
- 作者：Romagnani ; Paola ; Annunziato ; Francesco ; Baccari ; Maria C ; Parronchi ; Paola
- 关键词：APC antigen-presenting cell ; CD Crohn's disease ; Cys A Cyclosporin A ; IBD inflammatory bowel disease ; IL-2R IL-2 receptor ; iNOS inducible NO synthase ; LAG-3 lymphocyte activation gene-3 ; LP lamina propria ; NiBD non-inflammatory bowel disorders ; NO nitric
- 刊名：Current Opinion in Immunology
- 出版年：1997
- 期刊代码：24_09527915
- 类别：imm
- 出版时间：December, 1997
- 卷：9
- 期：6
- 页码：793-799
- 文件大小：1.08 M
摘要
Recent findings indicate that activated T lymphocytes, showing restricted T-cell receptor repertoire and a Th1-like profile of cytokine production, are responsible for macrophage activation and release of inflammatory cytokines, toxic oxygen metabolites and nitric oxide, which initiate and maintain the transmural intestinal inflammation in Crohn's disease. A critical event in the promotion of Th1-type response at gut level may involve up-regulation of IL-12 production and the breakdown of tolerance against the intestinal flora.