Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals

详细信息	查看全文 | 推荐本文 |

• 作者：Rosa Lapalombella¹ ; Yuh-Ying Yeh¹ ; Liwen Wang² ; Asha Ramanunni¹ ; Sarwish Rafiq¹ ; ³ ; Shruti Jha¹ ; Justin Staubli¹ ; ³ ; David&#160 ; M. Lucas¹ ; ⁵ ; Rajeswaran Mani¹ ; ⁴ ; Sarah&#160 ; E.M. Herman¹ ; ³ ; Amy&#160 ; J. Johnson¹ ; ⁵ ; Arletta Lozanski¹ ; Leslie Andritsos¹ ; Jeffrey Jones¹ ; Joseph&#160 ; M. Flynn¹ ; Brian Lannutti¹⁰ ; Peter Thompson¹¹ ; Paul Algate¹² ; Scott Stromatt¹² ; David Jarjoura⁶ ; Xiaokui Mo⁶ ; Dasheng Wang⁵ ; Ching-Shih Chen¹ ; ⁵ ; Gerard Lozanski⁷ ; Nyla&#160 ; A. Heerema⁷ ; Susheela Tridandapani⁸ ; Michael&#160 ; A. Freitas⁹ ; ¹³ ; Natarajan Muthusamy¹ ; ⁴ ; ⁹ ; ¹³ ; ^{raj.muthusamy@osumc.edu} ; John&#160 ; C. Byrd¹ ; ⁴ ; ⁵ ; ¹³ ; ^{john.byrd@osumc.edu}
• 刊名：Cancer Cell
• 出版年：2012
• 期刊代码：43_15356108
• 类别：med
• 出版时间：15 May, 2012
• 卷：21
• 期：5
• 页码：694-708
• 文件大小：1653 K

摘要

| Figures/TablesFigures/Tables | ReferencesReferences

Summary

Tetraspanins are commonly believed to act only as 鈥渕olecular facilitators,鈥?with no direct role in signal transduction. We herein demonstrate that upon ligation, CD37, a tetraspanin molecule expressed on mature normal and transformed B cells, becomes tyrosine phosphorylated, associates with proximal signaling molecules, and initiates a cascade of events leading to apoptosis. Moreover, we have identified two tyrosine residues with opposing regulatory functions: one lies in the N-terminal domain of CD37 in a predicted 鈥淚TIM-like鈥?motif and mediates SHP1-dependent death, whereas the second lies in a predicted 鈥淚TAM motif鈥?in the C-terminal domain of CD37 and counteracts death signals by mediating phosphatidylinositol 3-kinase-dependent survival.