Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression

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• 作者：Barch ; Deanna M. ; Sheline ; Yvette I. ; Csernansky ; John G. ; Snyder ; Abraham Z.
• 关键词：Schizophrenia ; major depression ; functional magnetic resonance imaging (fMRI) ; working memory ; cognition
• 刊名：Biological Psychiatry
• 出版年：2003
• 期刊代码：34_00063223
• 类别：med
• 出版时间：March 1, 2003
• 卷：53
• 期：5
• 页码：376-384
• 文件大小：198 K

摘要

A large number of studies suggest the presence of deficits in dorsolateral prefrontal cortex function during performance of working memory tasks in individuals with schizophrenia. However, working memory deficits may also present in other psychiatric disorders, such as major depression. It is not clear whether people with major depression also demonstrate impaired prefrontal activation during performance of working memory tasks.