Involvement of P2Y13 receptor in suppression of neuronal differentiation

详细信息	查看全文 | 推荐本文 |

• 作者：Shinya Yano^a ; Mitsutoshi Tsukimoto^a ; Hitoshi Harada^b ; Shuji Kojima^a ; ^{kjma@rs.noda.tus.ac.jp}
• 关键词：PC12 ; Neuronal differentiation ; Purinergic signaling ; P2Y13
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：14 June, 2012
• 卷：518
• 期：1
• 页码：5-9
• 文件大小：598 K

摘要

We examined the receptor-mediated effects of extracellular ATP on neuronal differentiation of PC12 cells, Neuro2a cells and MEB5 cells by using a series of receptor antagonists. The P2Y13 receptor antagonist MRS2211 significantly accelerated neurite outgrowth in all cases. Treatment with nerve growth factor (NGF) alone activated ERK1/2 in PC12 cells, and the activation was further increased by MRS2211. These results suggest involvement of P2Y13 receptor in suppression of neuronal differentiation. Thus, P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases.