A proton magnetic resonance spectroscopy study in schizoaffective disorder: Comparison of bipolar disorder and schziophrenia

详细信息	查看全文 | 推荐本文 |

• 作者：Demet Kalaycı ; ^a ; Osman Ö ; zdel^b ; Gü ; lfizar Sö ; zeri-Varma^b ; ^{gvarma@pau.edu.tr} ; Yı ; lmaz Kı ; roğ ; lu^c ; Selim Tü ; mkaya^b
• 关键词：H-MRS ; proton magnetic resonance spectroscopy ; BD ; bipolar disorder ; SAD ; schizoaffective disorder ; SCH ; schizophrenia ; DLPFC ; dorsolateral prefrontal cortex ; NAA ; N-acetyl aspartate ; Cho ; choline-containing compounds ; Cr ; creatine-containing compounds ; W
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2012
• 期刊代码：222_02785846
• 类别：med
• 出版时间：27 April, 2012
• 卷：37
• 期：1
• 页码：176-181
• 文件大小：196 K

摘要

The aim of this study was to compare schizoaffective disorder, bipolar disorder and schizophrenia based on ¹H-MRS metabolite values in dorsolateral prefrontal cortex and executive functions. The subjects comprised 15 patients with bipolar disorder type I (BD), 15 with schizophrenia (SCH), 15 with schizoaffective disorder (SAD) and 15 healthy controls. We performed proton magnetic resonance spectroscopy (¹H-MRS) of the dorsolateral prefrontal cortex (DLPFC) bilaterally. Levels of N-acetyl aspartate (NAA), choline-containing compounds (Cho) and creatine-containing compounds (Cr) were measured in the DLPFC using ¹H-MRS. We administered the Wisconsin Card Sorting Test (WCST) and the Stroop Test (ST) to evaluate executive functions. The SAD, BD and SCH patients had lower levels of NAA than the control group. The SAD and BD patients had low levels of Cho compared to the control group. The left DLPFC Cr levels in all of the patient groups and the right DLPFC Cr levels in the BD and SAD groups were lower than in the control group. The levels of NAA Cho and Cr were not related to executive functions and attention performance. Cr level were related to attention processes, only in SCH. Our results indicate that NAA levels are reduced in schizoaffective disorder, bipolar disorder and schizophrenia, but the reduction in the levels of NAA is not a distinctive feature among these three illnesses. Schizoaffective and bipolar disorders have similar features related to the levels of compounds containing Cho and Cr. This similarity may be related to these illnesses both having an affective basis.