Reticulocyte hemoglobin content allows early and reliable detection of functional iron deficiency in blood donors

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• 作者：M.J. Semmelrock^a ; ^e ; R.B. Raggam^b ; K. Amrein^c ; A. Avian^d ; K. Schallmoser^a ; G. Lanzer^a ; H.J. Semmelrock^b ; F. Prueller^b ; A. Berghold^d ; E. Rohde^f ; ^{e.rohde@salk.at}
• 关键词：IDA ; iron deficiency anemia ; Hb ; hemoglobin ; MCV ; mean corpuscular volume ; MCH ; mean corpuscular hemoglobin ; MCHC ; mean corpuscular hemoglobin concentration ; sTfR ; soluble transferrin receptor ; AIS ; absent iron stores ; sTfR-F ; ferritin index ; RBC ; red blo
• 刊名：Clinica Chimica Acta
• 出版年：2012
• 期刊代码：54_00098981
• 类别：med
• 出版时间：11 April, 2012
• 卷：413
• 期：7-8
• 页码：678-682
• 文件大小：387 K

摘要

Background

Frequent blood donations may lead to a depletion of body iron stores resulting in manifest anemia. Reticulocyte hemoglobin content (CHr) - a marker for impaired hemoglobinisation (IH) caused by functional iron deficiency (FID) - was investigated regarding its value as a routine screening parameter in frequent whole blood donors.

Methods

In a prospective study, 917 frequent blood donors and 688 first time or reactivated donors were tested for iron status and red blood cell count, including CHr. The ferritin index as a marker to indicate absent iron stores (AIS) was calculated.

Results

Depending on the number of donations during the preceding 12 months, AIS were detected in up to 21.4%of male and 27.8%of female donors, respectively. IH was present in up to 6.4%male and 16.7%female donors with 2 and 4 preceding donations, respectively. The defined CHr cut-off value was 28.0 pg to detect IH in frequent whole blood donors with AIS, leading to a test specificity of 98.2%(positive predictive value, PPV: 57.7%) in male and of 97.8%(PPV: 82.9%) in female donors.

Conclusion

Determination of CHr is feasible to detect FID resulting in IH in frequent blood donors. It may help to prevent the development of anemia in frequent blood donors and also can help to decide whether donor deferral or even iron substitution need to be recommended.