Antiteratogenic effects of α-naphthoflavone on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposed mice in utero
- 作者：Ja Young Jang ; Sunhee Shin ; Byong-il Choi ; Dongsun Park ; Jeong Hee Jeon ; Seock-Yeon Hwang ; Jong-Choon Kim ; Yun-Bae Kim ; Sang-Seop Nahm
- 关键词：2 ; 3 ; 7 ; 8-Tetrachlorodibenzo-p-dioxin (TCDD) ; Malformation ; Cleft palate ; Renal pelvic and ureteric dilatations ; Aryl hydrocarbon receptor (AhR) antagonist ; α ; -Naphthoflavone
- 刊名：Reproductive Toxicology
- 出版年：2007
- 期刊代码：233_08906238
- 类别：med
- 出版时间：November-December 2007
- 卷：24
- 期：3-4
- 页码：303-309
- 文件大小：467 K
摘要
The effects of α-naphthoflavone, an aryl hydrocarbon receptor (AhR) antagonist, on the reproductive toxicity and teratogenicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were investigated. Pregnant C57BL/6J mice were orally administered α-naphthoflavone either once on gestational day 12 (GD12; 50 μg/kg) or for 6 days (GD8–GD13; 5 mg/kg/day) followed by an oral challenge with TCDD (14 μg/kg) on GD12. Cesarean section was performed on GD18 for the evaluation of maternal and fetal toxicities. TCDD caused severe fetal malformations including cleft palate (43.7%) and renal pelvic and ureteric dilatations (100%). The administration of α-naphthoflavone either in a single treatment or 6-days remarkably reduced the incidence of cleft palate to 27.6%and 26.5%, respectively. In addition, the degree of renal pelvic and ureteric dilatations caused by TCDD were significantly attenuated by repeated treatment of α-naphthoflavone. These results suggest that AhR antagonists such as α-naphthoflavone could be promising candidates for reducing the incidence and severity of fetal malformations caused by TCDD exposure in utero.