The CD40–CD154 system in anti-infective host defense
- 作者：Grewal ; Iqbal S ; Borrow ; Persephone ; Pamer ; Eric G ; Oldstone ; Michael BA ; Flavell ; Richard A
- 关键词：APC antigen-presenting cell ; CTL cytotoxic T lymphocyte ; DC dendritic cell ; HIGM1 hyper IgM syndrome ; IFN interferon ; IL interleukin ; LCMV lymphocytic choriomeningitis virus ; MIP macrophage inflammatory protein ; NO nitric oxide ; SCID severe combined immun
- 刊名：Current Opinion in Immunology
- 出版年：1997
- 期刊代码：24_09527915
- 类别：imm
- 出版时间：August, 1997
- 卷：9
- 期：4
- 页码：491-497
- 文件大小：641 K
摘要
Research in the past few years has documented significant advances in our understanding of the CD40–CD40 ligand (CD154) system in diverse immune functions. This system influences many T cell mediated inflammatory immune responses and effector functions, unmasking a previously unexpected role for CD40–CD154 in cell mediated immunity. Manipulation of CD154 in animal models of infection by the use of CD154-deficient mice or anti-CD154 antibodies has shown the importance of this systemin the initiation of the inflammatory response, in the activation of antigen-presenting cells and in resistance to infections.