Effects of olfactory stimulation with isovaleric acid on brain activation in informed and naïve conditions: A functional MRI study

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• 作者：Yoriko Murata ; Fumino Okutani ; Mitsuhiko Nakahira ; Takahiro Ushida ; Tatsunori Ikemoto ; Isamu Yokoe ; Taizo Takeda ; Hideto Kaba ; Toshikazu Tani ; Yasuhiro Ogawa
• 关键词：Olfactory stimulation ; Isovaleric acid ; Functional magnetic resonance imaging ; Prior information
• 刊名：Auris Nasus Larynx
• 出版年：2007
• 期刊代码：29_03858146
• 类别：med
• 出版时间：December 2007
• 卷：34
• 期：4
• 页码：465-469
• 文件大小：283 K

摘要

To investigate the differences in regions of brain activation in response to olfactory stimulation by functional magnetic resonance imaging in conditions of prior warning of an odor and without.

Methods

Participants were 17 normal right-handed volunteers; 8 participants received prior warning of the odor (informed condition) and 9 participants were not pre-warned (naïve condition). The odorant used was isovaleric acid.

Results

In the informed condition with prior warning, activation was observed in the putamen extending to the insula, amygdala, and inferior frontal gyrus, and there was instant reification of the odor, while in the naïve condition without prior warning, activation was observed in the anterior cingulate cortex, entorhinal cortex, putamen and inferior frontal gyrus, and recognition of the odor was difficult.

Conclusions

These results suggest that the condition prior to olfactory stimulation, i.e., with or without prior warning, can affect recognition and regions of brain activation in response to olfactory stimulation using isovaleric acid. Differences in recognition and regions of brain activation between both conditions could be associated with response latencies, or degree of attention, expectation and/or concentration.