The effect of the neuroactive steroid α-THDOC, on staircase test behavior in mice

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• 作者：Weizman ; R. ; Peter ; Y. ; Terkel ; J. ; Gavish ; M. ; Pick ; C.G.
• 刊名：European Neuropsychopharmacology
• 出版年：1996
• 期刊代码：95_0924977x
• 类别：med
• 出版时间：September, 1996
• 卷：6
• 期：Supplement 4
• 页码：S4/150
• 文件大小：129 K

摘要

This study examined the effect of the neuroactive steroid 3α, 5α-tetrahydrocorticosterone (α-THDOC) as compared to benzodiazepines (diazepam and midazolam) and the barbiturate phenobarbital (PhB) on rearing (NR) and number of steps ascended (NSA) in the mouse staircase test. According to this paradigm NSA reflects locomotor activity and NR reflects anxiety. The two benzodiazepines, phenobarbital and α-THDOC reduced NR at doses that did not affect NSA. The NR lowering effect induced by the benzodiazepines and α-THDOC, but not PhB, was blocked by the benzodiazepine antagonist flumazenil. It appears that, although neuroactive steroids, like barbiturates, bind to distinct sites within the chloride ion channel of the gamma-aminobutyric acid type A (GABAA) receptor complex, α-THDOC behavioral activity is modulated by the benzodiazepine recognition site.