TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β
- 作者：Narendra Thapa ; Byung-Heon Lee ; In-San Kim
- 关键词：TGFBI ; β ; ig-h3 ; FAS1 domain ; Integrin ; Cell adhesion ; Tumorigenesis ; Angiogenesis ; Inflammation ; Osteogenesis ; Nephropathy ; Wound healing
- 刊名：The International Journal of Biochemistry and Cell Biology
- 出版年：2007
- 期刊代码：127_13572725
- 类别：med
- 出版时间：2007
- 卷：39
- 期：12
- 页码：2183-2194
- 文件大小：391 K
摘要
TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.