Polymorphisms of angiotensin II type 1 receptor gene and those of angiotensinogen point at culprit artery in ST-segment elevation myocardial infarction

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• 作者：Anna Konopka ; ^{akonopka@ikard.pl} ; ^{akonopka@ptkardio.pl} ; Ma艂gorzata Szperl ; Walerian Piotrowski ; Janina St臋pi艅ska
• 关键词：STEMI ; ST-segment elevation myocardial infarction ; MI ; myocardial infarction ; AGTR1 ; angiotensin II type 1 receptor ; A ; adenine ; C ; cytosine ; AGT ; angiotensinogen ; Met ; methionine ; Thr ; threonine ; OR ; odds ratio ; CAD ; coronary artery disease ; RAS ; renin&n
• 刊名：Gene
• 出版年：2012
• 期刊代码：73_03781119
• 类别：bio
• 出版时间：25 May, 2012
• 卷：500
• 期：1
• 页码：148-150
• 文件大小：138 K

摘要

The aim of the study was to determine whether the presence of angiotensin II type 1 receptor 1166A/C gene polymorphism and two polymorphisms of angiotensinogen, namely Met235Thr and Thr174Met, pointed at the culprit artery in patients with ST-segment elevation myocardial infarction (STEMI).

Methods

The AGTR1 1166A/C polymorphism and two AGT gene polymorphisms, Met235Thr and Thr174Met, were assessed in 100 patients with STEMI.

Results

The odds ratio (OR) of circumflex artery (CRX) responsible for STEMI was 3.49 (95%CI: 1.1-10.8, p < 0.05) for MetThr genotype for AGT Met235Thr gene and 4.54 (95%CI: 1.5-14.2, p < 0.01) for ThrMet genotype for AGT Thr174Met gene. Homozygous ThrThr genotype for AGT Thr174Met gene reduced OR of CRX as culprit artery in STEMI (OR = 0.29, 95%CI: 0.1-0.9, p < 0.05). However, the highest OR that increased up to 13.71 (95%CI: 1.58-119.3) was shown in case of right coronary artery and C/C genotype for AGTR1 1166A/C gene.

Conclusions

Polymorphism of AGTR1 1166A/C gene can point at the right coronary artery as infarct-related artery in STEMI. Polymorphisms of AGT Met235Thr and AGT Thr174Met genes are able to mark increased or reduced odds ratio of circumflex artery as culprit artery in STEMI.