Uterine fibroid pseudocapsule studied by transmission electron microscopy

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• 作者：Antonio Malvasi^a ; ^{antoniomalvasi@gmail.com} ; Carlo Cavallotti^b ; ^{cavallotti@uniroma1.it} ; Manrico Morroni^c ; ^{m.morroni@univpm.it} ; Teresa Lorenzi^c ; ^{teresalorenzi@yahoo.it} ; Domenico Dell&rsquo ; Edera^d ; ^{ducati98@libero.it} ; Giuseppe Nicolardi^e ; ^{giuseppe.nicolardi@unisalento.it} ; Andrea Tinelli^f ; ^{andreatinelli@gmail.com}
• 关键词：Uterine fibroid ; Uterine myoma ; Myoma pseudocapsule ; Laparoscopic myomectomy ; Uterine rupture ; Fertility ; Hysterectomy ; Intraoperative complications ; Postoperative compliance ; Surgical outcome ; Transmission electron microscopy
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：2012
• 期刊代码：92_03012115
• 类别：med
• 出版时间：June, 2012
• 卷：162
• 期：2
• 页码：187-191
• 文件大小：2092 K

摘要

Objective

The fibroid pseudocapsule is a structure which surrounds the uterine fibroid, separates it from the uterine tissue and contains a vascular network rich in neurotransmitters like a neurovascular bundle. The authors examined the composition of the fibroid pseudocapsule using electron microscopy.

Study design

Twenty non-pregnant patients were submitted to laparoscopic myomectomy by the intracapsular method and samples of the removed pseudocapsules were analyzed using transmission electron microscopy.

Results

At the ultrastructural level the pseudocapsule cells have the features of smooth muscle cells similar to the myometrium. So, the pseudocapsules are part of the myometrium which compresses the leiomyoma.

Conclusion

This ultrastructural feature suggests that when removing fibroids their pseudocapsules should be preserved. This study confirms preliminary evidence that pseudocapsules contain neuropeptides together with their related fibers, as a neurovascular bundle. The surgeon's behavior should be directed to carefully control and spare this muscular surrounding tissue during fibroid excision, in order to preserve the myometrium as much as possible.