Unrelated umbilical cord blood transplantation as salvage treatment for engraftment failure following autologous stem cell transplantation
- 作者：Rol ; Fenk ; Frank Neumann ; Barbara Fenk ; Leilani Ruf ; Fabian Zohren ; Nelly-Nancy Safaian ; Rainer Haas ; Guido Kobbe
- 关键词：Engraftment failure ; Umbilical cord blood ; Autologous transplantation
- 刊名：Leukemia Research
- 出版年：2008
- 期刊代码：186_01452126
- 类别：med
- 出版时间：July 2008
- 卷：32
- 期：7
- 页码：1157-1159
- 文件大小：233 K
摘要
We report a case of a patient with multiple myeloma and engraftment failure after high-dose therapy with autologous stem cell transplantation. After rescue treatment with G-CSF and back-up reinfusion of autologous stem cells failed, allogeneic umbilical cord blood transplantation resulted in neutrophil engraftment on day +16 and a 57 months lasting complete remission. This case report shows that umbilical cord blood transplantation is a rescue option after engraftment failure of autologous transplantation, which is available for 99%of patients due to the less stringent HLA matching criteria. Moreover, the prompt availability allows transplantation to be performed at an optimal time.