Trehalose glycolipids鈥攕ynthesis and biological activities

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• 作者：Ashna A. Khan^a ; ^b ; Bridget L. Stocker^b ; ^{bstocker@malaghan.org.nz} ; Mattie S.M. Timmer^a ; ^{mattie.timmer@vuw.ac.nz}
• 关键词：Trehalose glycolipids ; Chemical synthesis ; Biological activity ; 6 ; 6&prime ; -Diesters ; Sulfoglycolipids
• 刊名：Carbohydrate Research
• 出版年：2012
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：15 July, 2012
• 卷：356
• 期：Complete
• 页码：25-36
• 文件大小：1498 K

摘要

A variety of trehalose glycolipids have been isolated from natural sources, and several of these glycolipids exhibit important biological properties. These molecules also represent challenging synthetic targets due to their highly amphiphilic character, their large number of functional groups and additional chiral centres. This review highlights some of the recent advances made in the synthesis of trehalose glycolipids, and their associated biological activities.