Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice

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• 作者：Nakazono ; Manabu ; Hasegawa ; Shigeo ; Yamamoto ; Tsuneyuki ; Zaitsu ; Kiyoshi
• 关键词：Fullerene ; Catalepsy
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2004
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：November 15, 2004
• 卷：14
• 期：22
• 页码：5619-5621
• 文件大小：253 K

摘要

The 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene was synthesized from N,N芒芒芒-di(1-adamantyl)malondiamide and C₆₀ in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene. The intraperitoneal administration of this fullerene derivative (10mg/kg) caused an antagonistic effect on haloperidol-induced catalepsy in mice.