- 作者：Kirsten Boonstra ; k.boonstra@amc.uva.nl ; Ulrich Beuers ; Cyriel Y. Ponsioen
- 关键词：PSC ; primary sclerosing cholangitis ; PBC ; primary biliary cirrhosis ; IBD ; inflammatory bowel disease ; UDCA ; ursodeoxycolic acid ; MOOSE ; Meta-analysis Of Observational Studies in Epidemiology ; ICD ; International Classification of Diseases ; ERCP ; endoscopic
- 刊名：Journal of Hepatology
- 出版年：2012
- 期刊代码：162_01688278
- 类别：med
- 出版时间：May, 2012
- 卷：56
- 期：5
- 页码：1181-1188
- 文件大小：1092 K
Summary
Objective
Studies on the epidemiology of primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) show variable outcome. We aimed at systematically reviewing the incidence and prevalence rates, as well as geographical distribution and temporal trends of PSC and PBC.Data sources
A systematic search of literature was performed in Medline and EMBASE (search last conducted January 10th, 2011).
Study selection
Population-based epidemiological studies reporting incidence and/or prevalence rates for PSC or PBC in a defined geographical area of at least 100,000 adult inhabitants were considered relevant.
Data extraction
Study area, study period, number of patients, number of inhabitants, incidence per 100,000 inhabitants per year, prevalence per 100,000 inhabitants, method of case-finding, method of case-ascertainment, male/female ratio and in case of PSC, occurrence of inflammatory bowel diseases (IBD) were extracted from retrieved articles.
Results
The literature search yielded 2286 abstracts of which 31 articles fulfilled all inclusion criteria. Studies varied in size from 10 to 770 patients in catchment areas from 100,312 to 19,230,000 inhabitants. The incidence and prevalence rates for PSC range from 0 to 1.3 per 100,000 inhabitants/year and 0-16.2 per 100,000 inhabitants, respectively. PBC incidence rates range from 0.33 to 5.8 per 100,000 inhabitants/year and prevalence rates range from 1.91 to 40.2 per 100,000 inhabitants; prevalence rates are increasing in time.
Conclusions
Incidence and prevalence rates of both PSC and PBC vary widely and seem to be increasing. True population-based studies are scarce and therefore large population-based studies combining meticulous case-finding and case-ascertainment strategies are necessary.