Associations among birth weight, placental weight, gestational period and product quality indicators of umbilical cord blood units

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• 作者：Shu-Hui Wen^a ; Wan-Ling Zhao^b ; Py-Yu Lin^c ; Kuo-Liang Yang^c ; ^d ; ^{edward@tzuchi.com.tw}
• 关键词：Umbilical cord blood ; CD34 ; TNC ; Volume
• 刊名：Transfusion and Apheresis Science
• 出版年：2012
• 期刊代码：248_14730502
• 类别：med
• 出版时间：February, 2012
• 卷：46
• 期：1
• 页码：39-45
• 文件大小：320 K

摘要

Introduction

Numbers of CD34+ cell and total nucleated cell (TNC) and cord blood volume are commonly used as indicators for haematopoietic potential of umbilical cord blood (UCB) units. The purpose of this study was to investigate the relationship between donor-related factors and the quality indicators of UCB.

Methods

Obstetric and neonatal clinical laboratory data of a total of 1549 UCB units were obtained from Buddhist Tzu Chi Stem Cells Center (BTCSCC) Cord Blood Bank. A retrospective multivariate analysis was conducted to analyze the data.

Results

Our results showed that birth weight had positive correlations with each of the clinical features of CD34+ cell number, TNC count and unit volume of UCB, followed by the placental weight. Longer gestational period would decrease CD34+ cell number and volume of UCB. Female baby and mode of vaginal delivery of neonates were found to have larger amount of TNC in UCB.

Conclusion

Our results would be helpful and beneficial in building up standard criteria for evaluating stored UCB units.