In this study, a methodology is developed for flow simulation in ungauged catchments using a regionalisation and multi-model approach involving a suite of rainfall–runoff models and combination techniques. Daily observed hydrometeorological data for 12 French catchments are used for illustrating the procedures. Following a preliminary investigation of the regional homogeneity of that group of catchments, three regional flow simulation techniques are applied. Although all 12 catchments are gauged, initially each catchment is successively considered as being ungauged for the purpose of flow simulation in that catchment, their actual discharges being subsequently used for evaluating the performance of the flow estimation procedures for the catchment. The Nash-Sutcliffe efficiency index (R2) is used for assessing and ranking the relative performances of the regionalisation–model couples to identify the most appropriate couple for the region. The final step of applying that couple to a truly ungauged (13th) catchment in the region is described. Results are presented and conclusions drawn on the efficacy of the regional-multi-model approach. Of the couples considered, the pooling method of regionalisation coupled with the conceptual soil moisture accounting and routing (SMAR) model is deemed to be the best for simulating flow in an ungauged catchment in the region.